P2.27: Bortezomib for refractory autoimmune hemolytic anemia after intestinal transplantation

Successful treatment of IgM-mediated autoimmune hemolytic anemia with bortezomib.

Chronic cold agglutinin disease (CAD) is an acquired autoimmune hemolytic anemia (AIHA); usually due to the production of a monoclonal immunoglobulin M (IgM) protein directed against polysaccharide antigens on red blood cells.1,2 An occult lymphoproliferative disorder is often responsible for the production of the IgM paraprotein in patients with symptomatic CAD.3 The discovery of an underlying...

High-dose cyclophosphamide for refractory autoimmune hemolytic anemia.

High-dose cyclophosphamide, without stem cell rescue, has been used successfully to treat aplastic anemia and other autoimmune disorders. To determine the safety and efficacy of high-dose cyclophosphamide among patients with severe refractory autoimmune hemolytic anemia, we treated 9 patients with cyclophosphamide (50 mg. kg(-1). d(-1) for 4 days) who had failed a median of 3 (range, 1-7) other...

Autoimmune Hemolytic Anemia

Thymoma with Autoimmune Hemolytic Anemia

A 38-year-old Japanese male was referred to our hospital with abnormal chest X-ray results and severe Coombs-positive hemolytic anemia. He was diagnosed with a stage IV, WHO type A thymoma and was treated with oral prednisolone (1 mg/kg/day) and subsequent chemotherapy. After chemotherapy, the patient underwent surgical resection of the thymoma. Hemolysis rapidly disappeared and did not return ...

Immunotherapy-associated autoimmune hemolytic anemia

BACKGROUND Immunotherapy has been widely used in the treatment of several solid and hematologic malignancies. Checkpoint inhibitors have been the forefront of cancer immunotherapy in recent years. Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and programmed cell death 1 (PD-1) pathway are the prototypic checkpoint targets for immunotherapy. When combined, CTLA-4 and PD-1 checkpoint inhib...